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KMID : 0605720000060010103
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Journal of the Korean Society of Biological Therapies in Psychiatry
2000 Volume.6 No. 1 p.103 ~ p.110
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The Effects of Tianeptine, SSRIs and Moclobemide on Sexual Function
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권도훈/Do Hoon Kwon
강병조/Byung Jo Kang
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Abstract
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In this study, the author prospectively analyzed the effects of SSRIs, RIMA(moclobemide) and SSRE (tianeptine) on sexual function using a questionnaire. Among patients who visited the outpatient department of Kyungpook University Hospital from November 1998 to May 2000, the author included patients who met DSM-IV diagnostic criteria for depressive disorder. Sexual function and satisfaction was evaluated using a series of questions asked of each patient every 2 weeks for 8 weeks. Among 24 patients who completed the full 8 weeks of treatment, 8 received tianeptine(men 3, women 5), 7 received moclobemide(men 3, women 4), and 9 receded SSRIs(men 6, women 3). Of 8 tianeptine group, 7 reported total improvement in sexual function and satisfaction comparable to premorbid condition within 4 weeks of treatment, and another woman who had net experienced substantial improvement till 8 weeks had good tolerance in sexual function and reported some improvement in lubrication. Of 7 moclobemide group, 5 reported no significant differences in their sexual function associated with medication. In SSRI group, all patients complained of delayed ejaculation and anorgasmia associated with medication within 4 weeks of treatment, and among them 2 reported decreased libido and difficulty in erection (lubrication) in addition. But at 8 weeks, except for 1 female patient who couldn't tolerate general sexual dysfunction(especially anorgasmia) and was switched over to another antidepressant, 5 male patients reported no significant differences in their sexual function. The result of this study demonstrated that sexual dysfunction associated with SSRIs might be adapted in most cases when taken continuously and moclobemide had no significant association with sexual dysfunction. Tianeptine, in most depressive patients, recovered general sexual function including libido, erection (lubrication), ejaculation and orgasm to premorbid condition and might be a desirable drug of choice and an altermative in patients who complain of sexual dysfunction.
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KEYWORD
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Antidepressants, SSRIs, Moclobemide, Tianeptine, Sexual Dysfunction,
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